FDA-approved in June 2008, collagen-based filler Evolence, for the correction of moderate to deep facial wrinkles and folds such as nasolabial folds (those lines that extend from your nose to the corners of your mouth), while new to the United States, Evolence has been available in Canada, Europe and Israel for several years.
Derived from porcine collagen, Evolence is a filler that adds volume and structure to depleted facial areas. Evolence is a yellowish, opaque gel that is injected into the inner layers of facial skin (mid-to deep-dermis) to correct moderate to deep facial wrinkles and nasolabial folds. The porcine collagen is crosslinked using Glymatrix technology. Crosslinking is the chemical process of combining two different elements to create a new matrix or structure. In this case, porcine collagen is crosslinked with sugar to provide strength and long-lasting characteristics of the Evolence filler. The new matrix binds with the body's own natural collagen supply.
Collagen composes up to 80 percent of the skin. Its role is to maintain the skin's integrity, but collagen breaks down with advancing age. The breakdown of collagen during the aging process can lead to wrinkles, lines and folds. Results with Evolence are immediate and last for approximately six months. Additional data for 12-month duration approval is being filed with the FDA.
Side effects with Evolence may include injection-site reactions such as mild swelling, redness, and pain. Typically these go away from within hours to a few days. Other rare side effects with Evolence include the development of small areas of firmness under the skin at the treated sites. These lumps or bumps may be noticed when the areas are pressed upon.
No skin test is required with Evolence, because porcine collagen is genetically similar to human collagen. You should not choose Evolence if you are hypersensitive to any collagen products or porcine products, or if you have a history of severe allergies.Do not apply makeup immediately after treatment, and keep the treated area clean. Your doctor should give you instructions on when it is OK to wear makeup.
Evolence causes no allergic reaction. Unlike existing collagen treatments, which typically last 2-3 months, an Evolence treatment can last up to nine months in 95 percent of patients, according to one study. An Evolence treatment, which costs around $500, is more economical than existing collagen treatments because it lasts longer and saves you the cost of repeat treatments. Typically, the desired results are achieved with a single treatment. Unlike some wrinkle busting anti aging treatments like Botox, which can take 3-7 days to smoothen your facial lines, Evolence works immediately with minimal-to-no downtime. It causes minimal-to-no swelling or bruising allowing you to resume your daily activities almost immediately. |
